Is it safe to drive from the Grand Canyon to San Francisco ?

Very safe, but can't fall off the Rocky Mountains in winter, winter mountain pass, have to go around from the south, through Las Vegas, along the way to Death Valley, Bad Water, go to Bakersfield, along the way Yosemite (Yosemite) for a circle and then go to San Francisco, take a detour to Napa is also good

Now it's safe. In late December, pay attention to the weather forecast. The snow will block the mountains in the Grand Canyon area. When the mountains are not blocked, there is snow and ice on a section of the road, which is relatively dangerous.

There are few vehicles along the way, but I feel very safe. The Grand Canyon has a South Rim and a West Rim. The South Rim is far from Las Vegas, about 4-5 hours by car. That's the South Rim I went to.